|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human ASGPR1 ORF mammalian expression plasmid, C-GFPSpark tag||HG10773-ACG|
|Human ASGPR1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10773-ACR|
|Human ASGPR1 ORF mammalian expression plasmid, C-Flag tag||HG10773-CF|
|Human ASGPR1 ORF mammalian expression plasmid, C-His tag||HG10773-CH|
|Human ASGPR1 ORF mammalian expression plasmid, C-Myc tag||HG10773-CM|
|Human ASGPR1 ORF mammalian expression plasmid, C-HA tag||HG10773-CY|
|Human ASGPR1 Gene cDNA clone plasmid||HG10773-M|
|Human ASGPR1 ORF mammalian expression plasmid, N-Flag tag||HG10773-NF|
|Human ASGPR1 ORF mammalian expression plasmid, N-His tag||HG10773-NH|
|Human ASGPR1 ORF mammalian expression plasmid, N-Myc tag||HG10773-NM|
|Human ASGPR1 ORF mammalian expression plasmid, N-HA tag||HG10773-NY|
|Human ASGPR1 natural ORF mammalian expression plasmid||HG10773-UT|
|Learn more about expression Vectors|
The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.