|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human VTCN1 ORF mammalian expression plasmid, C-GFPSpark tag||HG10738-ACG|
|Human VTCN1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10738-ACR|
|Human VTCN1 ORF mammalian expression plasmid, C-Flag tag||HG10738-CF|
|Human VTCN1 ORF mammalian expression plasmid, C-His tag||HG10738-CH|
|Human VTCN1 ORF mammalian expression plasmid, C-Myc tag||HG10738-CM|
|Human VTCN1 ORF mammalian expression plasmid, C-HA tag||HG10738-CY|
|Human VTCN1 Gene cDNA clone plasmid||HG10738-M|
|Human VTCN1 natural ORF mammalian expression plasmid||HG10738-M-N|
|Human VTCN1 ORF mammalian expression plasmid, N-Flag tag||HG10738-NF|
|Human VTCN1 ORF mammalian expression plasmid, N-His tag||HG10738-NH|
|Human VTCN1 ORF mammalian expression plasmid, N-Myc tag||HG10738-NM|
|Human VTCN1 ORF mammalian expression plasmid, N-HA tag||HG10738-NY|
|Human VTCN1 natural ORF mammalian expression plasmid||HG10738-UT|
|Learn more about expression Vectors|
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type? membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X / VTCN1 / B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.