|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human CLIC4 ORF mammalian expression plasmid, C-GFPSpark tag||HG12271-ACG|
|Human CLIC4 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG12271-ACR|
|Human CLIC4 ORF mammalian expression plasmid, N-GFPSpark tag||HG12271-ANG|
|Human CLIC4 ORF mammalian expression plasmid, N-OFPSpark / RFP tag||HG12271-ANR|
|Human CLIC4 ORF mammalian expression plasmid, C-Flag tag||HG12271-CF|
|Human CLIC4 ORF mammalian expression plasmid, C-His tag||HG12271-CH|
|Human CLIC4 ORF mammalian expression plasmid, C-Myc tag||HG12271-CM|
|Human CLIC4 ORF mammalian expression plasmid, C-HA tag||HG12271-CY|
|Human CLIC4 Gene cDNA clone plasmid||HG12271-G|
|Human CLIC4 ORF mammalian expression plasmid, N-Flag tag||HG12271-NF|
|Human CLIC4 ORF mammalian expression plasmid, N-His tag||HG12271-NH|
|Human CLIC4 ORF mammalian expression plasmid, N-Myc tag||HG12271-NM|
|Human CLIC4 ORF mammalian expression plasmid, N-HA tag||HG12271-NY|
|Human CLIC4 natural ORF mammalian expression plasmid||HG12271-UT|
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Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains one GST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. CLIC4 could promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Expression of CLIC4 is prominent in heart, kidney, placenta and skeletal muscle. Overexpression of CLIC4 in cancer cells inhibits tumor growth. Conversely, overexpression of CLIC4 in tumor stromal cells stimulates tumor growth. Thus, CLIC4 participates in normal and pathological processes and may serve as a useful target for therapies in disturbances of homeostasis and neoplastic transformation. Loss of CLIC4 in tumor cells and gain in tumor stroma is common to many human cancers and marks malignant progression. Up-regulation of CLIC4 in tumor stroma is coincident with myofibroblast conversion, generally a poor prognostic indicator. Reactivation and restoration of CLIC4 in tumor cells or the converse in tumor stromal cells could provide a novel approach to inhibit tumor growth.