|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human FGF19 ORF mammalian expression plasmid, C-GFPSpark tag||HG12226-ACG|
|Human FGF19 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG12226-ACR|
|Human FGF19 ORF mammalian expression plasmid, C-Flag tag||HG12226-CF|
|Human FGF19 ORF mammalian expression plasmid, C-His tag||HG12226-CH|
|Human FGF19 ORF mammalian expression plasmid, C-Myc tag||HG12226-CM|
|Human FGF19 ORF mammalian expression plasmid, C-HA tag||HG12226-CY|
|Human FGF19 Gene cDNA clone plasmid||HG12226-G|
|Human FGF19 ORF mammalian expression plasmid, N-Flag tag||HG12226-NF|
|Human FGF19 ORF mammalian expression plasmid, N-His tag||HG12226-NH|
|Human FGF19 ORF mammalian expression plasmid, N-Myc tag||HG12226-NM|
|Human FGF19 ORF mammalian expression plasmid, N-HA tag||HG12226-NY|
|Human FGF19 natural ORF mammalian expression plasmid||HG12226-UT|
|Learn more about expression Vectors|
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. It interacts with KL and KLB directly. However, it interacts with FGFR4 in the presence of heparin, KL or KLB. FGF19 is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. It also stimulates glucose uptake in adipocytes.