|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human RLN1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11625-ACG|
|Human RLN1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11625-ACR|
|Human RLN1 ORF mammalian expression plasmid, C-Flag tag||HG11625-CF|
|Human RLN1 ORF mammalian expression plasmid, C-His tag||HG11625-CH|
|Human RLN1 ORF mammalian expression plasmid, C-Myc tag||HG11625-CM|
|Human RLN1 ORF mammalian expression plasmid, C-HA tag||HG11625-CY|
|Human RLN1 Gene cDNA clone plasmid||HG11625-M|
|Human RLN1 ORF mammalian expression plasmid, N-Flag tag||HG11625-NF|
|Human RLN1 ORF mammalian expression plasmid, N-His tag||HG11625-NH|
|Human RLN1 ORF mammalian expression plasmid, N-Myc tag||HG11625-NM|
|Human RLN1 ORF mammalian expression plasmid, N-HA tag||HG11625-NY|
|Human RLN1 natural ORF mammalian expression plasmid||HG11625-UT|
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Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein which belongs to the insulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductive hormone 80 years ago, relaxin has been implicated in a number of pregnancy-related functions involving extracellular matrix (ECM) turnover and collagen degradation. It is now becoming evident that relaxin's ability to reduce matrix synthesis and increase ECM degradation has important implications in several nonreproductive organs, including the heart, lung, kidney, liver and skin. The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1 (RNL1), relaxin-2 (RNL2) and relaxin-3 ( RNL3), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, INSL6 remain uncharacterised. Relaxin-1 / RLN1 is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. Relaxin-1 / RLN1 may be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Relaxin and estrogen appear to play protective roles against airway fibrosis, airway SM thickening, and cardiac hypertrophy. Relaxin may also provide a means to regulate excessive collagen deposition during kidney development and in diseased states characterized by renal fibrosis.