|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human RBP4 ORF mammalian expression plasmid, C-GFPSpark tag||HG10354-ACG|
|Human RBP4 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10354-ACR|
|Human RBP4 ORF mammalian expression plasmid, C-Flag tag||HG10354-CF|
|Human RBP4 ORF mammalian expression plasmid, C-His tag||HG10354-CH|
|Human RBP4 ORF mammalian expression plasmid, C-Myc tag||HG10354-CM|
|Human RBP4 ORF mammalian expression plasmid, C-HA tag||HG10354-CY|
|Human RBP4 Gene cDNA clone plasmid||HG10354-M|
|Human RBP4 ORF mammalian expression plasmid, N-Flag tag||HG10354-NF|
|Human RBP4 ORF mammalian expression plasmid, N-His tag||HG10354-NH|
|Human RBP4 ORF mammalian expression plasmid, N-Myc tag||HG10354-NM|
|Human RBP4 ORF mammalian expression plasmid, N-HA tag||HG10354-NY|
|Human RBP4 natural ORF mammalian expression plasmid||HG10354-UT|
|Learn more about expression Vectors|
Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).