|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human SNAP25 ORF mammalian expression plasmid, C-GFPSpark tag||HG11585-ACG|
|Human SNAP25 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11585-ACR|
|Human SNAP25 ORF mammalian expression plasmid, N-GFPSpark tag||HG11585-ANG|
|Human SNAP25 ORF mammalian expression plasmid, C-Flag tag||HG11585-CF|
|Human SNAP25 ORF mammalian expression plasmid, C-His tag||HG11585-CH|
|Human SNAP25 ORF mammalian expression plasmid, C-Myc tag||HG11585-CM|
|Human SNAP25 ORF mammalian expression plasmid, C-HA tag||HG11585-CY|
|Human SNAP25 Gene cDNA clone plasmid||HG11585-M|
|Human SNAP25 ORF mammalian expression plasmid, N-Flag tag||HG11585-NF|
|Human SNAP25 ORF mammalian expression plasmid, N-His tag||HG11585-NH|
|Human SNAP25 ORF mammalian expression plasmid, N-Myc tag||HG11585-NM|
|Human SNAP25 ORF mammalian expression plasmid, N-HA tag||HG11585-NY|
|Human SNAP25 natural ORF mammalian expression plasmid||HG11585-UT|
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Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein which belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the specificity of membrane fusion and to directly execute fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together. SNAP25 / SUP is a Q-SNARE protein contributing two α-helices in the formation of the exocytotic fusion complex in neurons where it assembles with syntaxin-1 and synaptobrevin. SNAP25 / SUP is involved in the molecular regulation of neurotransmitter release. It may play an important role in the synaptic function of specific neuronal systems. SNAP25 / SUP associates with proteins involved in vesicle docking and membrane fusion. SNAP25 / SUP regulates plasma membrane recycling through its interaction with CENPF. SNAP25 / SUP inhibits P/Q- and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP25 / SUP decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses.