|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human SerpinA3 ORF mammalian expression plasmid, C-GFPSpark tag||HG10307-ACG|
|Human SerpinA3 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10307-ACR|
|Human SerpinA3 ORF mammalian expression plasmid, C-Flag tag||HG10307-CF|
|Human SerpinA3 ORF mammalian expression plasmid, C-His tag||HG10307-CH|
|Human SerpinA3 ORF mammalian expression plasmid, C-Myc tag||HG10307-CM|
|Human SerpinA3 ORF mammalian expression plasmid, C-HA tag||HG10307-CY|
|Human SerpinA3 Gene cDNA clone plasmid||HG10307-M|
|Human SerpinA3 ORF mammalian expression plasmid, N-Flag tag||HG10307-NF|
|Human SerpinA3 ORF mammalian expression plasmid, N-His tag||HG10307-NH|
|Human SerpinA3 ORF mammalian expression plasmid, N-Myc tag||HG10307-NM|
|Human SerpinA3 ORF mammalian expression plasmid, N-HA tag||HG10307-NY|
|Human SerpinA3 natural ORF mammalian expression plasmid||HG10307-UT|
|Learn more about expression Vectors|
Human SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzyme is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease, and mutations of this gene have been observed in patients with Parkinson disease and chronic obstructive pulmonary disease. In addition, ACT gene polymorphism has been implicated with Alzheimer’s disease (AD), cerebral amyloid angiopathy (CAA), as well as stroke, since SerpinA3 is a major constituent of the plaques in AD and an inhibitor of amyloid beta peptide degradation.