|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human CD64 ORF mammalian expression plasmid, C-GFPSpark tag||HG10256-ACG|
|Human CD64 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10256-ACR|
|Human CD64 ORF mammalian expression plasmid, C-Flag tag||HG10256-CF|
|Human CD64 ORF mammalian expression plasmid, C-His tag||HG10256-CH|
|Human CD64 ORF mammalian expression plasmid, C-Myc tag||HG10256-CM|
|Human CD64 ORF mammalian expression plasmid, C-HA tag||HG10256-CY|
|Human CD64 Gene cDNA clone plasmid||HG10256-M|
|Human CD64 ORF mammalian expression plasmid, N-Flag tag||HG10256-NF|
|Human CD64 ORF mammalian expression plasmid, N-His tag||HG10256-NH|
|Human CD64 ORF mammalian expression plasmid, N-Myc tag||HG10256-NM|
|Human CD64 ORF mammalian expression plasmid, N-HA tag||HG10256-NY|
|Human CD64 natural ORF mammalian expression plasmid||HG10256-UT|
|Learn more about expression Vectors|
High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membrane glycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells. The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions. Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses.