|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human PCSK1 ORF mammalian expression plasmid, C-GFPSpark tag||HG10129-ACG|
|Human PCSK1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10129-ACR|
|Human PCSK1 ORF mammalian expression plasmid, C-Flag tag||HG10129-CF|
|Human PCSK1 ORF mammalian expression plasmid, C-His tag||HG10129-CH|
|Human PCSK1 ORF mammalian expression plasmid, C-Myc tag||HG10129-CM|
|Human PCSK1 ORF mammalian expression plasmid, C-HA tag||HG10129-CY|
|Human PCSK1 Gene cDNA clone plasmid||HG10129-M|
|Human PCSK1 natural ORF mammalian expression plasmid||HG10129-M-N|
|Human PCSK1 ORF mammalian expression plasmid, N-Flag tag||HG10129-NF|
|Human PCSK1 ORF mammalian expression plasmid, N-His tag||HG10129-NH|
|Human PCSK1 ORF mammalian expression plasmid, N-Myc tag||HG10129-NM|
|Human PCSK1 ORF mammalian expression plasmid, N-HA tag||HG10129-NY|
|Human PCSK1 natural ORF mammalian expression plasmid||HG10129-UT|
|Learn more about expression Vectors|
Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleave after a single arginine. It binds to a protein known as proSAAS, which also represents its endogenous inhibitor. PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. PCSK1 substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency). PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction. It is due to impaired processing of prohormones.