|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human CDH17 ORF mammalian expression plasmid, C-GFPSpark tag||HG11360-ACG|
|Human CDH17 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11360-ACR|
|Human CDH17 ORF mammalian expression plasmid, C-Flag tag||HG11360-CF|
|Human CDH17 ORF mammalian expression plasmid, C-His tag||HG11360-CH|
|Human CDH17 ORF mammalian expression plasmid, C-Myc tag||HG11360-CM|
|Human CDH17 ORF mammalian expression plasmid, C-HA tag||HG11360-CY|
|Human CDH17 Gene cDNA clone plasmid||HG11360-M|
|Human CDH17 natural ORF mammalian expression plasmid||HG11360-M-N|
|Human CDH17 ORF mammalian expression plasmid, N-Flag tag||HG11360-NF|
|Human CDH17 ORF mammalian expression plasmid, N-His tag||HG11360-NH|
|Human CDH17 ORF mammalian expression plasmid, N-Myc tag||HG11360-NM|
|Human CDH17 ORF mammalian expression plasmid, N-HA tag||HG11360-NY|
|Human CDH17 natural ORF mammalian expression plasmid||HG11360-UT|
|Learn more about expression Vectors|
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.