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Rat CDH13 / Cadherin-13 / H Cadherin Protein (Fc Tag)

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CDH13Protein Product Information
Synonym:CDH13
Protein Construction:A DNA sequence encoding the rat CDH13 (NP_620244.1)(Met1-Ala692) was expressed with the Fc region of human IgG1 at the C-terminus.
Species:Rat
Expressed Host:Human Cells
Form & Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
CDH13Protein QC Testing
Purity:(53+40.8) % as determined by SDS-PAGE
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Ala 22
Molecule Mass:The recombinant rat CDH13/Fc is a disulfide-linked homodimer. The reduced monomer comprises 912 amino acids and has a predicted molecular mass of 100.5 kDa. The apparent molecular mass of the protein is approximately 102 and 52 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation:Lyophilized from sterile 25mM MES, 0.15M NaCl, pH 6.5.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
CDH13Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
80280-R02H
Background

CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer.

References
  • Hart AB. et al., 2012, PLoS One. 7 (8): e42646.
  • Xu J. et al., 2012, BMC Cancer. 12: 243.
  • Jo J. et al., 2012, Obesity (Silver Spring). 20 (8): 1683-7.
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    Catalog:80280-R02H-50
    List Price: $178.00  (Save $0.00)
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    • Rat CDH13 / Cadherin-13 / H Cadherin Protein (Fc Tag) SDS-PAGE
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