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Rat IL17RA / IL17R Protein (His Tag)

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Rat IL17RA Protein Product Information
Synonym:IL17RA
Protein Construction:A DNA sequence encoding the rat IL17RA (NP_001101353.2) (Met1-Pro320) was expressed, fused with a polyhistidine tag at the C-terminus.
Species:Rat
Expressed Host:Human Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Rat IL17RA Protein QC Testing
Purity:> 95 % as determined by SDS-PAGE
Bio-Activity:1. Measured by its binding ability in a functional ELISA. Immobilized rat IL17RA-His at 10 μg/ml (100 μl/well) can bind biotinylated human IL17A (Cat:12047-HNAE), The EC50 of biotinylated human IL17A (Cat:12047-HNAE) is 5-11.8 ng/ml.
2.Measured by its binding ability in a functional ELISA. Immobilized mouse IL17a (Cat:51065-MNAE) at 10 μg/ml (100 μl/well) can bind rat IL17RA-His, The EC50 of rat IL17RA-His is 0.44-1.02 μg/mL.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Ser 32
Molecule Mass:The recombinant rat IL17RA comprises 300 amino acids and predicts a molecular mass of 34.1 kDa. The apparent molecular mass of the recombinant protein is approximately 52-58 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Rat IL17RA Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Rat IL17RA Protein SDS-PAGE
Rat IL17RA / IL17R Protein (His Tag) SDS-PAGE
Rat IL17RA / IL17R Protein (His Tag) SDS-PAGE
Other IL17RA Recombinant Protein Products
80190-R08H
IL-17R/IL-17RA (CD217) Background

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

Rat IL-17R/IL-17RA (CD217) References
  • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
  • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
  • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.
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    Catalog: 80190-R08H-100
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"