|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human HSPD1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11322-ACG|
|Human HSPD1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11322-ACR|
|Human HSPD1 ORF mammalian expression plasmid, N-GFPSpark tag||HG11322-ANG|
|Human HSPD1 ORF mammalian expression plasmid, N-OFPSpark / RFP tag||HG11322-ANR|
|Human HSPD1 ORF mammalian expression plasmid, C-Flag tag||HG11322-CF|
|Human HSPD1 ORF mammalian expression plasmid, C-His tag||HG11322-CH|
|Human HSPD1 ORF mammalian expression plasmid, C-Myc tag||HG11322-CM|
|Human HSPD1 ORF mammalian expression plasmid, C-HA tag||HG11322-CY|
|Human HSPD1 Gene cDNA clone plasmid||HG11322-M|
|Human HSPD1 ORF mammalian expression plasmid, N-Flag tag||HG11322-NF|
|Human HSPD1 ORF mammalian expression plasmid, N-His tag||HG11322-NH|
|Human HSPD1 ORF mammalian expression plasmid, N-Myc tag||HG11322-NM|
|Human HSPD1 ORF mammalian expression plasmid, N-HA tag||HG11322-NY|
|Human HSPD1 natural ORF mammalian expression plasmid||HG11322-UT|
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HSPD1, also known as HSP60, is a member of the chaperonin family. HSPD1 may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. It may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HSPD1 gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13). Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4); also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. HSPD1 is cinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first two decades of life.