|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human ENPP2 ORF mammalian expression plasmid, C-GFPSpark tag||HG11308-ACG|
|Human ENPP2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11308-ACR|
|Human ENPP2 ORF mammalian expression plasmid, C-Flag tag||HG11308-CF|
|Human ENPP2 ORF mammalian expression plasmid, C-His tag||HG11308-CH|
|Human ENPP2 ORF mammalian expression plasmid, C-Myc tag||HG11308-CM|
|Human ENPP2 ORF mammalian expression plasmid, C-HA tag||HG11308-CY|
|Human ENPP2 Gene cDNA clone plasmid||HG11308-M|
|Human ENPP2 ORF mammalian expression plasmid, Flag tag||HG11308-M-F|
|Human ENPP2 ORF mammalian expression plasmid, N-Flag tag||HG11308-NF|
|Human ENPP2 ORF mammalian expression plasmid, N-His tag||HG11308-NH|
|Human ENPP2 ORF mammalian expression plasmid, N-Myc tag||HG11308-NM|
|Human ENPP2 ORF mammalian expression plasmid, N-HA tag||HG11308-NY|
|Human ENPP2 natural ORF mammalian expression plasmid||HG11308-UT|
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ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid (LPA), which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion. ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness. Thus, Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics. In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection.