|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human FLRT2 ORF mammalian expression plasmid, C-GFPSpark tag||HG11296-ACG|
|Human FLRT2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11296-ACR|
|Human FLRT2 ORF mammalian expression plasmid, C-Flag tag||HG11296-CF|
|Human FLRT2 ORF mammalian expression plasmid, C-His tag||HG11296-CH|
|Human FLRT2 ORF mammalian expression plasmid, C-Myc tag||HG11296-CM|
|Human FLRT2 ORF mammalian expression plasmid, C-HA tag||HG11296-CY|
|Human FLRT2 Gene cDNA clone plasmid||HG11296-M|
|Human FLRT2 ORF mammalian expression plasmid, N-Flag tag||HG11296-NF|
|Human FLRT2 ORF mammalian expression plasmid, N-His tag||HG11296-NH|
|Human FLRT2 ORF mammalian expression plasmid, N-Myc tag||HG11296-NM|
|Human FLRT2 ORF mammalian expression plasmid, N-HA tag||HG11296-NY|
|Human FLRT2 natural ORF mammalian expression plasmid||HG11296-UT|
|Learn more about expression Vectors|
Fibronectin Leucine-Rich Transmembrane (FLRT) proteins are glycosylated membrane proteins expressed at the cell surface which localise in a homophilic manner to cell-cell contacts expressing the focal adhesion marker vinculin. FLRT1, FLRT2, and FLRT3, the three genes encode putative type I transmembrane proteins, each containing 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT family members may function in cell adhesion and/or receptor signalling. Each member of the FLRT family has a distinct, highly regulated expression pattern, as was seen for the NLRR family. FLRT2 is expressed in a subset of the sclerotome, adjacent to the region that forms the syndetome, suggesting that interaction with FGF signalling may be a general property of FLRT proteins. All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. FLRT proteins have a dual role, promoting FGF signalling and modulating homotypic cell adhesion. FLRT2 played critical roles in craniofacial development, and it was also present in the vomero-nasal organ, mandibular primodia, and the posterior aspects of the unfused and fused secondary palatal shelves.