|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human JAM3 ORF mammalian expression plasmid, C-GFPSpark tag||HG13152-ACG|
|Human JAM3 ORF mammalian expression plasmid, C-Flag tag||HG13152-CF|
|Human JAM3 ORF mammalian expression plasmid, C-His tag||HG13152-CH|
|Human JAM3 ORF mammalian expression plasmid, C-Myc tag||HG13152-CM|
|Human JAM3 ORF mammalian expression plasmid, C-HA tag||HG13152-CY|
|Human JAM3 Gene cDNA Clone (full-length ORF Clone)||HG13152-G|
|Human JAM3 ORF mammalian expression plasmid, N-Flag tag||HG13152-NF|
|Human JAM3 ORF mammalian expression plasmid, N-His tag||HG13152-NH|
|Human JAM3 ORF mammalian expression plasmid, N-Myc tag||HG13152-NM|
|Human JAM3 ORF mammalian expression plasmid, N-HA tag||HG13152-NY|
|Human JAM3 natural ORF mammalian expression plasmid||HG13152-UT|
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Junctional Adhesion Molecule C Protein & Antibody (JAM-C, JAM3 Protein) also known as Junctional adhesion molecule 3, JAM3, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. It is an adhesion molecule expressed by endothelial cells (ECs) that plays a role in tight junction formation, leukocyte adhesion, and transendothelial migration. JAM-C is an adhesion molecule that is expressed on cells within the vascular compartment and epithelial cells and, to date, has been largely studied in the context of inflammatory events. JAM-C is also expressed in peripheral nerves and that this expression is localized to Schwann cells at junctions between adjoining myelin end loops. JAM-C is a component of the autotypic junctional attachments of Schwann cells and plays an important role in maintaining the integrity and function of myelinated peripheral nerves. JAM-C was recently shown to be a counter receptor for the leukocyte beta2-integrin Mac-1 (CD11b/CD18), thereby mediating interactions between vascular cells, particularly in inflammatory cell recruitment. JAM-C is up-regulated by oxidized low-density lipoprotein (LDL) and may thereby contribute to increased inflammatory cell recruitment during atherosclerosis. JAM-C may therefore provide a novel molecular target for antagonizing interactions between vascular cells in atherosclerosis. JAM-C was shown to undergo a heterophilic interaction with the leukocyte beta2 integrin Mac-1, thereby mediating interactions between vascular cells in inflammatory cell recruitment. JAM-C undergoes a homophilic interaction via the Arg64-Ile65-Glu66 motif on the membrane-distal Ig domain of the molecule. The homophilic interaction of JAM-C can mediate tumor cell-endothelial cell interactions and may thereby be involved in the process of tumor cell metastasis.