|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human CADM1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11168-ACG|
|Human CADM1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11168-ACR|
|Human CADM1 ORF mammalian expression plasmid, C-Flag tag||HG11168-CF|
|Human CADM1 ORF mammalian expression plasmid, C-His tag||HG11168-CH|
|Human CADM1 ORF mammalian expression plasmid, C-Myc tag||HG11168-CM|
|Human CADM1 ORF mammalian expression plasmid, C-HA tag||HG11168-CY|
|Human CADM1 Gene cDNA clone plasmid||HG11168-M|
|Human CADM1 ORF mammalian expression plasmid, N-Flag tag||HG11168-NF|
|Human CADM1 ORF mammalian expression plasmid, N-His tag||HG11168-NH|
|Human CADM1 ORF mammalian expression plasmid, N-Myc tag||HG11168-NM|
|Human CADM1 ORF mammalian expression plasmid, N-HA tag||HG11168-NY|
|Human CADM1 natural ORF mammalian expression plasmid||HG11168-UT|
|Learn more about expression Vectors|
Members of the immunoglobulin superfamily often play key roles in intercellular adhesion. IGSF4 is a novel immunoglobulin (Ig)-like intercellular adhesion molecule. Three Ig-like domains are included in the extracellular domain of IGSF4 and mediate homophilic or heterophilic interactions independently of Ca2+. The cytoplasmic domain of IGSF4 contains the binding motifs that connect to actin fibers. Since IGSF4 has been characterized by several independent research groups, this molecule is called by three names, TSLC1, SgIGSF and SynCAM. IGSF4 was first characterized as a tumor suppressor of non-small cell lung cancer and termed TSLC1. It is a single-pass type I membrane protein which belongs to the nectin family, which may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. In addition, CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. In neuroblastoma, loss of CADM1 expression has recently been found in disseminated tumours with adverse outcome, prompting us to investigate its role in neuroblastoma tumour progression. The downregulation of CADM1 tumour suppressor gene expression is a critical event in neuroblastoma pathogenesis resulting in tumour progression.