|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Canine IL2RB ORF mammalian expression plasmid, C-GFPSpark tag||DG70082-ACG|
|Canine IL2RB ORF mammalian expression plasmid, C-OFPSpark / RFP tag||DG70082-ACR|
|Canine IL2RB ORF mammalian expression plasmid, C-Flag tag||DG70082-CF|
|Canine IL2RB ORF mammalian expression plasmid, C-His tag||DG70082-CH|
|Canine IL2RB ORF mammalian expression plasmid, C-Myc tag||DG70082-CM|
|Canine IL2RB ORF mammalian expression plasmid, C-HA tag||DG70082-CY|
|Canine IL2RB Gene cDNA clone plasmid||DG70082-G|
|Canine IL2RB ORF mammalian expression plasmid, N-Flag tag||DG70082-NF|
|Canine IL2RB ORF mammalian expression plasmid, N-His tag||DG70082-NH|
|Canine IL2RB ORF mammalian expression plasmid, N-Myc tag||DG70082-NM|
|Canine IL2RB ORF mammalian expression plasmid, N-HA tag||DG70082-NY|
|Canine IL2RB natural ORF mammalian expression plasmid||DG70082-UT|
|Learn more about expression Vectors|
Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.