|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Canine IL18R1 ORF mammalian expression plasmid, C-Flag tag||DG70081-CF|
|Canine IL18R1 ORF mammalian expression plasmid, C-His tag||DG70081-CH|
|Canine IL18R1 ORF mammalian expression plasmid, C-Myc tag||DG70081-CM|
|Canine IL18R1 ORF mammalian expression plasmid, C-HA tag||DG70081-CY|
|Canine IL18R1 ORF mammalian expression plasmid, N-Flag tag||DG70081-NF|
|Canine IL18R1 ORF mammalian expression plasmid, N-His tag||DG70081-NH|
|Canine IL18R1 ORF mammalian expression plasmid, N-Myc tag||DG70081-NM|
|Canine IL18R1 ORF mammalian expression plasmid, N-HA tag||DG70081-NY|
|Canine IL18R1 natural ORF mammalian expression plasmid||DG70081-UT|
|Learn more about expression Vectors|
Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.