|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Canine IL13RA2 ORF mammalian expression plasmid, C-GFPSpark tag||DG70079-ACG|
|Canine IL13RA2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||DG70079-ACR|
|Canine IL13RA2 ORF mammalian expression plasmid, C-Flag tag||DG70079-CF|
|Canine IL13RA2 ORF mammalian expression plasmid, C-His tag||DG70079-CH|
|Canine IL13RA2 ORF mammalian expression plasmid, C-Myc tag||DG70079-CM|
|Canine IL13RA2 ORF mammalian expression plasmid, C-HA tag||DG70079-CY|
|Canine IL13RA2 Gene cDNA clone plasmid||DG70079-G|
|Canine IL13RA2 ORF mammalian expression plasmid, N-Flag tag||DG70079-NF|
|Canine IL13RA2 ORF mammalian expression plasmid, N-His tag||DG70079-NH|
|Canine IL13RA2 ORF mammalian expression plasmid, N-Myc tag||DG70079-NM|
|Canine IL13RA2 ORF mammalian expression plasmid, N-HA tag||DG70079-NY|
|Canine IL13RA2 natural ORF mammalian expression plasmid||DG70079-UT|
|Learn more about expression Vectors|
Interleukin-13 receptor subunit alpha-2 (IL13RA2/IL-13RA2) is also known as also known as cluster of differentiation 213A2 (CD213A2), IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, and IL-13RA2. The IL13RA2 is often overexpressed in brain tumors, making Il13ra2 one of the vaccine targets for immunotherapy of glioma. IL13RA2/IL-13RA2 is a cancer-associated receptor that is present in greater than 80% of High Grade Astrocytomas (HGA) and has recently been recognized as a cytokine that predisposes breast cancer cells to metastasize. Expression of IL13Rα2 was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to ligands present in fetal bovine serum in the medium. None of the malignant glioma cell lines cultivated in vitro and tested to date exhibited the IL13Rα2 receptor. A recombinant virus (R5111) enters cells via its interaction with the IL13Rα2 receptor in a manner that cannot be differentiated from the interaction of wild-type virus with its receptors.