|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Canine IL11RA ORF mammalian expression plasmid, C-GFPSpark tag||DG70078-ACG|
|Canine IL11RA ORF mammalian expression plasmid, C-OFPSpark / RFP tag||DG70078-ACR|
|Canine IL11RA ORF mammalian expression plasmid, C-Flag tag||DG70078-CF|
|Canine IL11RA ORF mammalian expression plasmid, C-His tag||DG70078-CH|
|Canine IL11RA ORF mammalian expression plasmid, C-Myc tag||DG70078-CM|
|Canine IL11RA ORF mammalian expression plasmid, C-HA tag||DG70078-CY|
|Canine IL11RA Gene cDNA clone plasmid||DG70078-G|
|Canine IL11RA ORF mammalian expression plasmid, N-Flag tag||DG70078-NF|
|Canine IL11RA ORF mammalian expression plasmid, N-His tag||DG70078-NH|
|Canine IL11RA ORF mammalian expression plasmid, N-Myc tag||DG70078-NM|
|Canine IL11RA ORF mammalian expression plasmid, N-HA tag||DG70078-NY|
|Canine IL11RA natural ORF mammalian expression plasmid||DG70078-UT|
|Learn more about expression Vectors|
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.