|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Canine LTA ORF mammalian expression plasmid, C-GFPSpark tag||DG70066-ACG|
|Canine LTA ORF mammalian expression plasmid, C-OFPSpark / RFP tag||DG70066-ACR|
|Canine LTA ORF mammalian expression plasmid, C-Flag tag||DG70066-CF|
|Canine LTA ORF mammalian expression plasmid, C-His tag||DG70066-CH|
|Canine LTA ORF mammalian expression plasmid, C-Myc tag||DG70066-CM|
|Canine LTA ORF mammalian expression plasmid, C-HA tag||DG70066-CY|
|Canine LTA Gene cDNA clone plasmid||DG70066-G|
|Canine LTA ORF mammalian expression plasmid, N-Flag tag||DG70066-NF|
|Canine LTA ORF mammalian expression plasmid, N-His tag||DG70066-NH|
|Canine LTA ORF mammalian expression plasmid, N-Myc tag||DG70066-NM|
|Canine LTA ORF mammalian expression plasmid, N-HA tag||DG70066-NY|
|Canine LTA natural ORF mammalian expression plasmid||DG70066-UT|
|Learn more about expression Vectors|
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1 and TNFB, is a secreted protein which belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is a highly inducible, secreted, and exists as homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNF-beta/TNFSF1/Lymphotoxin alpha forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1/Lymphotoxin alpha is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNF-beta/TNFSF1/Lymphotoxin alpha are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.