|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human CHI3L2 ORF mammalian expression plasmid, C-GFPSpark tag||HG12162-ACG|
|Human CHI3L2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG12162-ACR|
|Human CHI3L2 ORF mammalian expression plasmid, C-Flag tag||HG12162-CF|
|Human CHI3L2 ORF mammalian expression plasmid, C-His tag||HG12162-CH|
|Human CHI3L2 ORF mammalian expression plasmid, C-Myc tag||HG12162-CM|
|Human CHI3L2 ORF mammalian expression plasmid, C-HA tag||HG12162-CY|
|Human CHI3L2 Gene cDNA clone plasmid||HG12162-G|
|Human CHI3L2 ORF mammalian expression plasmid, N-Flag tag||HG12162-NF|
|Human CHI3L2 ORF mammalian expression plasmid, N-His tag||HG12162-NH|
|Human CHI3L2 ORF mammalian expression plasmid, N-Myc tag||HG12162-NM|
|Human CHI3L2 ORF mammalian expression plasmid, N-HA tag||HG12162-NY|
|Human CHI3L2 natural ORF mammalian expression plasmid||HG12162-UT|
|Learn more about expression Vectors|
Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. It highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in bone and cartilage. A better understanding of the immune response against cartilage-related components including YKL-39 may help to elucidate the pathological processes of arthritic disorders. Up regulation of YKL-39/CHI3L2 in osteoarthritic cartilage suggests that YKL-39/CHI3L2 may be a more accurate marker of chondrocyte activation than YKL-40, although it has yet to be established as a suitable marker in synovial fluid and serum. The decreased expression of YKL-40 by osteoarthritic chondrocytes is surprising as increased levels have been reported in rheumatoid and osteoarthritic synovial fluid, where it may derive from activated synovial cells or osteophytic tissue or by increased matrix destruction in the osteoarthritic joint. YKL-39 and YKL-40 are potentially interesting marker molecules for arthritic joint disease because they are abundantly expressed by both normal and osteoarthritic chondrocytes.