|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Canine IL12B ORF mammalian expression plasmid, C-GFPSpark tag||DG70011-ACG|
|Canine IL12B ORF mammalian expression plasmid, C-OFPSpark / RFP tag||DG70011-ACR|
|Canine IL12B ORF mammalian expression plasmid, C-Flag tag||DG70011-CF|
|Canine IL12B ORF mammalian expression plasmid, C-His tag||DG70011-CH|
|Canine IL12B ORF mammalian expression plasmid, C-Myc tag||DG70011-CM|
|Canine IL12B ORF mammalian expression plasmid, C-HA tag||DG70011-CY|
|Canine IL12B Gene cDNA clone plasmid||DG70011-M|
|Canine IL12B ORF mammalian expression plasmid, N-Flag tag||DG70011-NF|
|Canine IL12B ORF mammalian expression plasmid, N-His tag||DG70011-NH|
|Canine IL12B ORF mammalian expression plasmid, N-Myc tag||DG70011-NM|
|Canine IL12B ORF mammalian expression plasmid, N-HA tag||DG70011-NY|
|Canine IL12B natural ORF mammalian expression plasmid||DG70011-UT|
|Learn more about expression Vectors|
Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.