|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human TTR ORF mammalian expression plasmid, C-GFPSpark tag||HG12091-ACG|
|Human TTR ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG12091-ACR|
|Human TTR ORF mammalian expression plasmid, C-Flag tag||HG12091-CF|
|Human TTR ORF mammalian expression plasmid, C-His tag||HG12091-CH|
|Human TTR ORF mammalian expression plasmid, C-Myc tag||HG12091-CM|
|Human TTR ORF mammalian expression plasmid, C-HA tag||HG12091-CY|
|Human TTR Gene cDNA clone plasmid||HG12091-G|
|Human TTR ORF mammalian expression plasmid, N-Flag tag||HG12091-NF|
|Human TTR ORF mammalian expression plasmid, N-His tag||HG12091-NH|
|Human TTR ORF mammalian expression plasmid, N-Myc tag||HG12091-NM|
|Human TTR ORF mammalian expression plasmid, N-HA tag||HG12091-NY|
|Human TTR natural ORF mammalian expression plasmid||HG12091-UT|
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Prealbumin/Transthyretin, also known as ATTR, Prealbumin, TTR and PALB, is a secreted and cytoplasm protein which belongs to the Prealbumin / Transthyretin family. Prealbumin / Transthyretin is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Prealbumin / Transthyretin has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Prealbumin/Transthyretin is a carrier protein. It transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. Defects in Prealbumin / Transthyretin are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to Prealbumin / Transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.