|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human REG1B ORF mammalian expression plasmid, C-GFPSpark tag||HG11638-ACG|
|Human REG1B ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11638-ACR|
|Human REG1B ORF mammalian expression plasmid, C-Flag tag||HG11638-CF|
|Human REG1B ORF mammalian expression plasmid, C-His tag||HG11638-CH|
|Human REG1B ORF mammalian expression plasmid, C-Myc tag||HG11638-CM|
|Human REG1B ORF mammalian expression plasmid, C-HA tag||HG11638-CY|
|Human REG1B Gene cDNA clone plasmid||HG11638-M|
|Human REG1B ORF mammalian expression plasmid, N-Flag tag||HG11638-NF|
|Human REG1B ORF mammalian expression plasmid, N-His tag||HG11638-NH|
|Human REG1B ORF mammalian expression plasmid, N-Myc tag||HG11638-NM|
|Human REG1B ORF mammalian expression plasmid, N-HA tag||HG11638-NY|
|Human REG1B natural ORF mammalian expression plasmid||HG11638-UT|
|Learn more about expression Vectors|
Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells, and could be associated with fibrocalculous pancreatopathy. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family consisting of four subtypes (types I, II, III, IV) and are involved in cancers and neurodegenerative diseases. Regenerating islet-derived 1 beta (REG1B), also known as Lithostathine-1-beta and Pancreatic stone protein 2 (PSPS2), is a types I Reg protein and contains one typical C-type lectin domain. REG1B is a 166-amino acid protein which has 22 amino acid substitutions in comparison with the previously isolated human REG1A, and it is was expressed only in pancreas. REG1B Is normally found in the exocrine pancreas, whereas in other tissues it appears either only under pathological conditions, such as Alzheimer's disease (brain), cancer (colon), or during regeneration such as neuronal sprouting in brain and pancreas regeneration. REG1B might act as an inhibitor of spontaneous calcium carbonate precipitation. The REG1A and REG1B gene and proteins could play different roles in the pancreas.