|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human NETO1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11562-ACG|
|Human NETO1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11562-ACR|
|Human NETO1 ORF mammalian expression plasmid, C-Flag tag||HG11562-CF|
|Human NETO1 ORF mammalian expression plasmid, C-His tag||HG11562-CH|
|Human NETO1 ORF mammalian expression plasmid, C-Myc tag||HG11562-CM|
|Human NETO1 ORF mammalian expression plasmid, C-HA tag||HG11562-CY|
|Human NETO1 Gene cDNA clone plasmid||HG11562-M|
|Human NETO1 ORF mammalian expression plasmid, N-Flag tag||HG11562-NF|
|Human NETO1 ORF mammalian expression plasmid, N-His tag||HG11562-NH|
|Human NETO1 ORF mammalian expression plasmid, N-Myc tag||HG11562-NM|
|Human NETO1 ORF mammalian expression plasmid, N-HA tag||HG11562-NY|
|Human NETO1 natural ORF mammalian expression plasmid||HG11562-UT|
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Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus representing a novel subfamily of CUB- and LDLa-containing proteins. The cytoplasmic domains of NETO1 and NETO2 are not homologous to other known protein sequences but contain a conserved FXNPXY-like motif, which is essential for the internalization of clathrin coated pits during endocytosis or alternatively, may be implicated in intracellular signaling pathways. NETO1 and NETO2, have marked effects on receptor properties, increasing further the potential diversity of Kainate receptors (KARs) functional properties. NETO1 involves in the development and/or maintenance of neuronal circuitry. NETO1 regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.