|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human TCN2 ORF mammalian expression plasmid, C-GFPSpark tag||HG10566-ACG|
|Human TCN2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10566-ACR|
|Human TCN2 ORF mammalian expression plasmid, C-Flag tag||HG10566-CF|
|Human TCN2 ORF mammalian expression plasmid, C-His tag||HG10566-CH|
|Human TCN2 ORF mammalian expression plasmid, C-Myc tag||HG10566-CM|
|Human TCN2 ORF mammalian expression plasmid, C-HA tag||HG10566-CY|
|Human TCN2 Gene cDNA clone plasmid||HG10566-M|
|Human TCN2 ORF mammalian expression plasmid, N-Flag tag||HG10566-NF|
|Human TCN2 ORF mammalian expression plasmid, N-His tag||HG10566-NH|
|Human TCN2 ORF mammalian expression plasmid, N-Myc tag||HG10566-NM|
|Human TCN2 ORF mammalian expression plasmid, N-HA tag||HG10566-NY|
|Human TCN2 natural ORF mammalian expression plasmid||HG10566-UT|
|Learn more about expression Vectors|
Transcobalamin II, also known as TCN2 and TC II, is a plasma protein that binds cobalamin (Cbl; vitamin B12) as it is absorbed in the terminal ileum and distributes to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis. Transcobalamin II is a non-glycolated secretory protein of molecular mass 43 kDa. Its plasma membrane receptor (TC II-R) is a heavily glycosylated protein with a monomeric molecular mass of 62 kDa. Human TCN2 gene is composed of nine exons and eight introns spanning approximately 20 kb with multiple potential transcription start sites. A number of genetic abnormalities are characterized either by a failure to express TCN2 or by synthesis of an abnormal protein. The TCN2 deficiency results in cellular cobalamin deficiency, an early onset of megaloblastic anaemia, and neurological abnormalities.