|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human TFPI ORF mammalian expression plasmid, C-GFPSpark tag||HG10564-ACG|
|Human TFPI ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10564-ACR|
|Human TFPI ORF mammalian expression plasmid, C-Flag tag||HG10564-CF|
|Human TFPI ORF mammalian expression plasmid, C-His tag||HG10564-CH|
|Human TFPI ORF mammalian expression plasmid, C-Myc tag||HG10564-CM|
|Human TFPI ORF mammalian expression plasmid, C-HA tag||HG10564-CY|
|Human TFPI Gene cDNA clone plasmid||HG10564-M|
|Human TFPI ORF mammalian expression plasmid, Flag tag||HG10564-M-F|
|Human TFPI ORF mammalian expression plasmid, N-Flag tag||HG10564-NF|
|Human TFPI ORF mammalian expression plasmid, N-His tag||HG10564-NH|
|Human TFPI ORF mammalian expression plasmid, N-Myc tag||HG10564-NM|
|Human TFPI ORF mammalian expression plasmid, N-HA tag||HG10564-NY|
|Human TFPI natural ORF mammalian expression plasmid||HG10564-UT|
|Learn more about expression Vectors|
Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is emphasized by how its activity is modulated in human disease. In a factor (F) Xa-dependent feedback system, TFPI binds directly and inhibits the TF-FVII/FVIIa complex. Normally, TFPI exists in plasma both as a full-length molecule and as variably carboxy-terminal truncated forms. TFPI also circulates in complex with plasma lipoproteins. The levels and the dual inhibitor effect of TFPI on FXa and TF-FVII/FVIIa complex offers insight into the mechanisms of various pathological conditions triggered by TF. TFPI may play an important role in modulating TF-induced thrombogenesis and it may also provide a unique therapeutic approach for prophylaxis and/or treatment of various diseases. In addition, Studies have shown that TFPI exhibits antiangiogenic and antimetastatic effects in vitro and in vivo. In animal models of experimental metastasis, both circulating and tumor cell-associated TFPI are shown to significantly reduce tumor cell-induced coagulation activation and lung metastasis.