|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human TFPI2 ORF mammalian expression plasmid, C-GFPSpark tag||HG10545-ACG|
|Human TFPI2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10545-ACR|
|Human TFPI2 ORF mammalian expression plasmid, N-GFPSpark tag||HG10545-ANG|
|Human TFPI2 ORF mammalian expression plasmid, N-OFPSpark / RFP tag||HG10545-ANR|
|Human TFPI2 ORF mammalian expression plasmid, C-Flag tag||HG10545-CF|
|Human TFPI2 ORF mammalian expression plasmid, C-His tag||HG10545-CH|
|Human TFPI2 ORF mammalian expression plasmid, C-Myc tag||HG10545-CM|
|Human TFPI2 ORF mammalian expression plasmid, C-HA tag||HG10545-CY|
|Human TFPI2 Gene cDNA clone plasmid||HG10545-M|
|Human TFPI2 ORF mammalian expression plasmid, N-Flag tag||HG10545-NF|
|Human TFPI2 ORF mammalian expression plasmid, N-His tag||HG10545-NH|
|Human TFPI2 ORF mammalian expression plasmid, N-Myc tag||HG10545-NM|
|Human TFPI2 ORF mammalian expression plasmid, N-HA tag||HG10545-NY|
|Human TFPI2 natural ORF mammalian expression plasmid||HG10545-UT|
|Learn more about expression Vectors|
Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 is highly abundant in the full-term placenta and widely expressed in various adult human tissues, such as the liver, skeletal muscle, heart, kidney, and pancreas. The expression of TFPI2 in tumors is inversely related to an increasing degree of malignancy, which may suggest a role for TFPI2 in the maintenance of tumor stability and inhibition of the growth of neoplasms. TFPI2 inhibits the tissue factor/factor VIIa (TF/VIIa) complex and a wide variety of serine proteinases including plasmin, plasma kallikrein, factor XIa, trypsin, and chymotrypsin. TFPI2 is involved in regulating pericellular proteases implicated in a variety of physiologic and pathologic processes including cancer cell invasion, vascular inflammation, and atherosclerosis. TFPI2 has also been shown to induce apoptosis and inhibit angiogenesis, which may contribute significantly to tumor growth inhibition.