|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human ADAM15 ORF mammalian expression plasmid, C-GFPSpark tag||HG10517-ACG|
|Human ADAM15 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10517-ACR|
|Human ADAM15 ORF mammalian expression plasmid, C-Flag tag||HG10517-CF|
|Human ADAM15 ORF mammalian expression plasmid, C-His tag||HG10517-CH|
|Human ADAM15 ORF mammalian expression plasmid, C-Myc tag||HG10517-CM|
|Human ADAM15 ORF mammalian expression plasmid, C-HA tag||HG10517-CY|
|Human ADAM15 Gene cDNA clone plasmid||HG10517-M|
|Human ADAM15 ORF mammalian expression plasmid, N-Flag tag||HG10517-NF|
|Human ADAM15 ORF mammalian expression plasmid, N-His tag||HG10517-NH|
|Human ADAM15 ORF mammalian expression plasmid, N-Myc tag||HG10517-NM|
|Human ADAM15 ORF mammalian expression plasmid, N-HA tag||HG10517-NY|
|Human ADAM15 natural ORF mammalian expression plasmid||HG10517-UT|
|Learn more about expression Vectors|
ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.