|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rhesus TLR2 ORF mammalian expression plasmid, C-GFPSpark tag||CG90254-ACG|
|Rhesus TLR2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||CG90254-ACR|
|Rhesus TLR2 ORF mammalian expression plasmid, C-Flag tag||CG90254-CF|
|Rhesus TLR2 ORF mammalian expression plasmid, C-His tag||CG90254-CH|
|Rhesus TLR2 ORF mammalian expression plasmid, C-Myc tag||CG90254-CM|
|Rhesus TLR2 ORF mammalian expression plasmid, C-HA tag||CG90254-CY|
|Rhesus TLR2 Gene cDNA clone plasmid||CG90254-G|
|Rhesus TLR2 ORF mammalian expression plasmid, N-Flag tag||CG90254-NF|
|Rhesus TLR2 ORF mammalian expression plasmid, N-His tag||CG90254-NH|
|Rhesus TLR2 ORF mammalian expression plasmid, N-Myc tag||CG90254-NM|
|Rhesus TLR2 ORF mammalian expression plasmid, N-HA tag||CG90254-NY|
|Rhesus TLR2 natural ORF mammalian expression plasmid||CG90254-UT|
|Learn more about expression Vectors|
TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathogen recognition and activation of innate immunity. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 contains 14 LRR (leucine-rich) repeats and 1 TIR domain. TLR2 gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. CD282 cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. It also cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. CD282 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It may also promote apoptosis in response to lipoproteins.