|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human ICOS ORF mammalian expression plasmid, C-GFPSpark tag||HG10344-ACG|
|Human ICOS ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10344-ACR|
|Human ICOS ORF mammalian expression plasmid, C-Flag tag||HG10344-CF|
|Human ICOS ORF mammalian expression plasmid, C-His tag||HG10344-CH|
|Human ICOS ORF mammalian expression plasmid, C-Myc tag||HG10344-CM|
|Human ICOS ORF mammalian expression plasmid, C-HA tag||HG10344-CY|
|Human ICOS Gene cDNA clone plasmid||HG10344-M|
|Human ICOS ORF mammalian expression plasmid, N-Flag tag||HG10344-NF|
|Human ICOS ORF mammalian expression plasmid, N-His tag||HG10344-NH|
|Human ICOS ORF mammalian expression plasmid, N-Myc tag||HG10344-NM|
|Human ICOS ORF mammalian expression plasmid, N-HA tag||HG10344-NY|
|Human ICOS natural ORF mammalian expression plasmid||HG10344-UT|
|Learn more about expression Vectors|
Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness.