|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human SerpinA5 ORF mammalian expression plasmid, C-GFPSpark tag||HG10309-ACG|
|Human SerpinA5 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10309-ACR|
|Human SerpinA5 ORF mammalian expression plasmid, C-Flag tag||HG10309-CF|
|Human SerpinA5 ORF mammalian expression plasmid, C-His tag||HG10309-CH|
|Human SerpinA5 ORF mammalian expression plasmid, C-Myc tag||HG10309-CM|
|Human SerpinA5 ORF mammalian expression plasmid, C-HA tag||HG10309-CY|
|Human SerpinA5 Gene cDNA clone plasmid||HG10309-M|
|Human SerpinA5 ORF mammalian expression plasmid, N-Flag tag||HG10309-NF|
|Human SerpinA5 ORF mammalian expression plasmid, N-His tag||HG10309-NH|
|Human SerpinA5 ORF mammalian expression plasmid, N-Myc tag||HG10309-NM|
|Human SerpinA5 ORF mammalian expression plasmid, N-HA tag||HG10309-NY|
|Human SerpinA5 natural ORF mammalian expression plasmid||HG10309-UT|
|Learn more about expression Vectors|
Serpin A5, also well known as protein C inhibitor (PCI), is a member of the human serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, serpinA5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin, and plays a role in the processes of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.