|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rhesus IL27RA ORF mammalian expression plasmid, C-GFPSpark tag||CG90129-ACG|
|Rhesus IL27RA ORF mammalian expression plasmid, C-OFPSpark / RFP tag||CG90129-ACR|
|Rhesus IL27RA ORF mammalian expression plasmid, C-Flag tag||CG90129-CF|
|Rhesus IL27RA ORF mammalian expression plasmid, C-His tag||CG90129-CH|
|Rhesus IL27RA ORF mammalian expression plasmid, C-Myc tag||CG90129-CM|
|Rhesus IL27RA ORF mammalian expression plasmid, C-HA tag||CG90129-CY|
|Rhesus IL27RA Gene cDNA clone plasmid||CG90129-G|
|Rhesus IL27RA ORF mammalian expression plasmid, N-Flag tag||CG90129-NF|
|Rhesus IL27RA ORF mammalian expression plasmid, N-His tag||CG90129-NH|
|Rhesus IL27RA ORF mammalian expression plasmid, N-Myc tag||CG90129-NM|
|Rhesus IL27RA ORF mammalian expression plasmid, N-HA tag||CG90129-NY|
|Rhesus IL27RA natural ORF mammalian expression plasmid||CG90129-UT|
|Learn more about expression Vectors|
The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit and glycoprotein 130. WSX-1/IL-27R, a class I cytokine receptor that is homologous to the β2 chain of the IL-12R in both sequence and structure, is highly expressed by resting/naive CD4+ T cells and CD8+ T cells. WSX-1/IL-27R belongs to the IL-6/IL-12 family of cytokines and induced proliferation of naive CD4(+) T cells and the generation of a Th1-type adaptive immune response. WSX-1/IL-27R functions as a receptor for IL27. IL-27 not only contributes to the development of an adaptive immune response through its action on CD4(+) T cells, it also directly acts on cells of the innate immune system. WSX-1/IL-27R requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. It is involved in the regulation of Th1-type immune responses. IL-27R also appears to be involved in innate defense mechanisms. IL27RA is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.