|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human LDLR ORF mammalian expression plasmid, C-GFPSpark tag||HG10231-ACG|
|Human LDLR ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10231-ACR|
|Human LDLR ORF mammalian expression plasmid, C-Flag tag||HG10231-CF|
|Human LDLR ORF mammalian expression plasmid, C-His tag||HG10231-CH|
|Human LDLR ORF mammalian expression plasmid, C-Myc tag||HG10231-CM|
|Human LDLR ORF mammalian expression plasmid, C-HA tag||HG10231-CY|
|Human LDLR Gene cDNA clone plasmid||HG10231-M|
|Human LDLR natural ORF mammalian expression plasmid||HG10231-M-N|
|Human LDLR ORF mammalian expression plasmid, N-Flag tag||HG10231-NF|
|Human LDLR ORF mammalian expression plasmid, N-His tag||HG10231-NH|
|Human LDLR ORF mammalian expression plasmid, N-Myc tag||HG10231-NM|
|Human LDLR ORF mammalian expression plasmid, N-HA tag||HG10231-NY|
|Human LDLR natural ORF mammalian expression plasmid||HG10231-UT|
|Learn more about expression Vectors|
LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.