|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human TLR3 ORF mammalian expression plasmid, C-GFPSpark tag||HG10190-ACG|
|Human TLR3 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10190-ACR|
|Human TLR3 ORF mammalian expression plasmid, N-GFPSpark tag||HG10190-ANG|
|Human TLR3 ORF mammalian expression plasmid, C-Flag tag||HG10190-CF|
|Human TLR3 ORF mammalian expression plasmid, C-His tag||HG10190-CH|
|Human TLR3 ORF mammalian expression plasmid, C-Myc tag||HG10190-CM|
|Human TLR3 ORF mammalian expression plasmid, C-HA tag||HG10190-CY|
|Human TLR3 Gene cDNA clone plasmid||HG10190-G|
|Human TLR3 ORF mammalian expression plasmid, N-Flag tag||HG10190-NF|
|Human TLR3 ORF mammalian expression plasmid, N-His tag||HG10190-NH|
|Human TLR3 ORF mammalian expression plasmid, N-Myc tag||HG10190-NM|
|Human TLR3 ORF mammalian expression plasmid, N-HA tag||HG10190-NY|
|Human TLR3 natural ORF mammalian expression plasmid||HG10190-UT|
|Learn more about expression Vectors|
Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses.