|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human SFTPD ORF mammalian expression plasmid, C-GFPSpark tag||HG11041-ACG|
|Human SFTPD ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11041-ACR|
|Human SFTPD ORF mammalian expression plasmid, C-Flag tag||HG11041-CF|
|Human SFTPD ORF mammalian expression plasmid, C-His tag||HG11041-CH|
|Human SFTPD ORF mammalian expression plasmid, C-Myc tag||HG11041-CM|
|Human SFTPD ORF mammalian expression plasmid, C-HA tag||HG11041-CY|
|Human SFTPD Gene cDNA clone plasmid||HG11041-M|
|Human SFTPD ORF mammalian expression plasmid, N-Flag tag||HG11041-NF|
|Human SFTPD ORF mammalian expression plasmid, N-His tag||HG11041-NH|
|Human SFTPD ORF mammalian expression plasmid, N-Myc tag||HG11041-NM|
|Human SFTPD ORF mammalian expression plasmid, N-HA tag||HG11041-NY|
|Human SFTPD natural ORF mammalian expression plasmid||HG11041-UT|
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Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. The polymorphic variation in the N-terminal domain of the SP-D molecule influences oligomerization, function, and the concentration of the molecule in serum. SFTPD is produced primarily by alveolar type II cells and nonciliated bronchiolar cells in the lung and is constitutively secreted into the alveoli where it influences surfactant homeostasis, effector cell functions, and host defense. It is upregulated in a variety of inflammatory and infectious conditions including Pneumocystis pneumonia and asthma. SFTPD is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Thus, recombinant SFTPD has been proposed as a therapeutical option for cystic fibrosis, neonatal lung disease and smoking-induced emphysema. Furthermore, SFTPD serum levels can be used as disease activity markers for interstitial lung diseases.