Quick Order

Text Size:AAA

VNN2 / Vanin-2 Antibody (FITC), Mouse MAb

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
Human VNN2 Antibody Product Information
Immunogen:Recombinant Human VNN2 / Vanin-2 protein (Catalog#11728-H08H)
Clone ID:04
Ig Type:Mouse IgG1
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human VNN2 / Vanin-2 (rh VNN2 / Vanin-2; Catalog#11728-H08H; NP_004656.2; Met 1-Ser 492) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Human VNN2 Antibody Usage Guide
Specificity:Human VNN2 / Vanin-2
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human VNN2 Antibody FC Application Image
[Click to enlarge image]
Flow cytometric analysis of anti-human VNN2 on human whole blood monocytes (left panel) and granulocytes (right panel). The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable monocytes and granulocytes.
VNN2 / Vanin-2 Antibody (FITC), Mouse MAb, Flow cytometric
Other VNN2 Antibody Products
VNN2/Vanin-2 Background

Vascular non-inflammatory molecule 2, also known as glycosyl-phosphatidyl inositol-anchored protein GPI-80, Vanin-2, Protein FOAP-4 and VNN2, is a cell membrane protein which belongs to the CN hydrolase family and Vanin subfamily. VNN2 is widely expressed with higher expression in spleen and blood. VNN2 is a member of the vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. VNN2 is an amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. It is involved in the thymus homing of bone marrow cells. VNN2 plays a role in transendothelial migration of neutrophils and may regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.

Human VNN2/Vanin-2 References
  • Suzuki K. et al., 1999, J. Immunol. 162: 4277-84.
  • Martin, F. et al., 2001,Immunogenetics. 53 (4):296-306.
  • Liu T.et al., 2005, J. Proteome Res. 4: 2070-80.
  • Jansen P.AM. et al., 2009, J. Invest. Dermatol. 129: 2167-74.
  • Product nameProduct name