|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rhesus PDGFC ORF mammalian expression plasmid, C-GFPSpark tag||CG90031-ACG|
|Rhesus PDGFC ORF mammalian expression plasmid, C-OFPSpark / RFP tag||CG90031-ACR|
|Rhesus PDGFC ORF mammalian expression plasmid, C-Flag tag||CG90031-CF|
|Rhesus PDGFC ORF mammalian expression plasmid, C-His tag||CG90031-CH|
|Rhesus PDGFC ORF mammalian expression plasmid, C-Myc tag||CG90031-CM|
|Rhesus PDGFC ORF mammalian expression plasmid, C-HA tag||CG90031-CY|
|Rhesus PDGFC Gene cDNA clone plasmid||CG90031-G|
|Rhesus PDGFC ORF mammalian expression plasmid, N-Flag tag||CG90031-NF|
|Rhesus PDGFC ORF mammalian expression plasmid, N-His tag||CG90031-NH|
|Rhesus PDGFC ORF mammalian expression plasmid, N-Myc tag||CG90031-NM|
|Rhesus PDGFC ORF mammalian expression plasmid, N-HA tag||CG90031-NY|
|Rhesus PDGFC natural ORF mammalian expression plasmid||CG90031-UT|
|Learn more about expression Vectors|
PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma pathways. PDGF-C acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. PDGF-C Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs.