|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human CDH8 ORF mammalian expression plasmid, C-GFPSpark tag||HG10144-ACG|
|Human CDH8 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10144-ACR|
|Human CDH8 ORF mammalian expression plasmid, C-Flag tag||HG10144-CF|
|Human CDH8 ORF mammalian expression plasmid, C-His tag||HG10144-CH|
|Human CDH8 ORF mammalian expression plasmid, C-Myc tag||HG10144-CM|
|Human CDH8 ORF mammalian expression plasmid, C-HA tag||HG10144-CY|
|Human CDH8 Gene cDNA clone plasmid||HG10144-M|
|Human CDH8 ORF mammalian expression plasmid, Flag tag||HG10144-M-F|
|Human CDH8 ORF mammalian expression plasmid, N-Flag tag||HG10144-NF|
|Human CDH8 ORF mammalian expression plasmid, N-His tag||HG10144-NH|
|Human CDH8 ORF mammalian expression plasmid, N-Myc tag||HG10144-NM|
|Human CDH8 ORF mammalian expression plasmid, N-HA tag||HG10144-NY|
|Human CDH8 natural ORF mammalian expression plasmid||HG10144-UT|
|Learn more about expression Vectors|
Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Type I cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherin 8, also known as CDH 8, is a type I I classical cadherin belonging to the cadherin superfamily. As mainly expressed in brain, CDH8 is found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts, and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Human Cadherin 8 is a 799 amino acid single-pass type I transmembrane protein with a putative 29 aa signal sequence, and a 32 aa propeptide, a 560 aa mature extracellular domain, a 21 aa transmembrane domain and a 157 aa cytoplasmic domain. The human, mouse and rat proteins share approximately 98% homology.