|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human MS4A1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11007-ACG|
|Human MS4A1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11007-ACR|
|Human MS4A1 ORF mammalian expression plasmid, C-Flag tag||HG11007-CF|
|Human MS4A1 ORF mammalian expression plasmid, C-His tag||HG11007-CH|
|Human MS4A1 ORF mammalian expression plasmid, C-Myc tag||HG11007-CM|
|Human MS4A1 ORF mammalian expression plasmid, C-HA tag||HG11007-CY|
|Human MS4A1 Gene cDNA clone plasmid||HG11007-M|
|Human MS4A1 natural ORF mammalian expression plasmid||HG11007-M-N|
|Human MS4A1 ORF mammalian expression plasmid, N-Flag tag||HG11007-NF|
|Human MS4A1 ORF mammalian expression plasmid, N-His tag||HG11007-NH|
|Human MS4A1 ORF mammalian expression plasmid, N-Myc tag||HG11007-NM|
|Human MS4A1 ORF mammalian expression plasmid, N-HA tag||HG11007-NY|
|Human MS4A1 natural ORF mammalian expression plasmid||HG11007-UT|
|Learn more about expression Vectors|
CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.