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Dectin-1 / CLEC7A Antibody (PE), Rabbit MAb

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Mouse CLEC7A Antibody Product Information
Immunogen:Recombinant Mouse Dectin-1 / CLEC7A protein (Catalog#50233-M07H)
Clone ID:010
Ig Type:Rabbit IgG
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Dectin-1 / CLEC7A (rM Dectin-1 / CLEC7A; Catalog#50233-M07H; NP_064392.2; Phe69-Leu244) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Mouse CLEC7A Antibody Usage Guide
Specificity:Mouse Dectin-1 / CLEC7A
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Mouse CLEC7A Antibody FC Application Image
[Click to enlarge image]
Profile of anti-Dectin/CLEC7A reactivity on Raw264.7 cells analyzed by flow cytometry.
Dectin-1 / CLEC7A Antibody (PE), Rabbit MAb, Flow cytometric
Other CLEC7A Antibody Products
Dectin-1/CLEC7A Background

Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.

Mouse Dectin-1/CLEC7A References
  • Herre J, et al. (2004) The role of Dectin-1 in antifungal immunity. Crit Rev Immunol. 24(3): 193-203.
  • Brown GD. (2006) Dectin-1: a signalling non-TLR pattern-recognition receptor. 6(1): 33-43.
  • Sun L, et al. (2007) The biological role of dectin-1 in immune response. Int Rev Immunol. 26(5-6): 349-64.
  • Schorey JS, et al. (2008) The pattern recognition receptor Dectin-1: from fungi to mycobacteria. Curr Drug Targets. 9(2): 123-9.
  • Reid DM, et al. (2009) Pattern recognition: recent insights from Dectin-1. Curr Opin Immunol. 21(1): 30-7.
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