|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human CPE ORF mammalian expression plasmid, C-GFPSpark tag||HG10069-ACG|
|Human CPE ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10069-ACR|
|Human CPE ORF mammalian expression plasmid, C-Flag tag||HG10069-CF|
|Human CPE ORF mammalian expression plasmid, C-His tag||HG10069-CH|
|Human CPE ORF mammalian expression plasmid, C-Myc tag||HG10069-CM|
|Human CPE ORF mammalian expression plasmid, C-HA tag||HG10069-CY|
|Human CPE Gene cDNA clone plasmid||HG10069-M|
|Human CPE ORF mammalian expression plasmid, Flag tag||HG10069-M-F|
|Human CPE natural ORF mammalian expression plasmid||HG10069-M-N|
|Human CPE ORF mammalian expression plasmid, N-Flag tag||HG10069-NF|
|Human CPE ORF mammalian expression plasmid, N-His tag||HG10069-NH|
|Human CPE ORF mammalian expression plasmid, N-Myc tag||HG10069-NM|
|Human CPE ORF mammalian expression plasmid, N-HA tag||HG10069-NY|
|Human CPE natural ORF mammalian expression plasmid||HG10069-UT|
|Learn more about expression Vectors|
Human carboxypeptidase E (CPE), also known as Carboxypeptidase H, is a peripheral membrane protein and a zinc metallocarboxypeptidase, and the conversion of proCPE into CPE occurs primarily in secretory vesicles. The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. The enzymatic activity is enhanced by millimolar concentrations of Co2+. It has also been proposed that membrane-associated carboxypeptidase E acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway.Its interaction with glycosphingolipid-cholesterol rafts at the TGN facilitates the targeting. Mutations in this gene are implicated in type I I diabetes due to impaired glucose clearance and insulin resistance.