|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Human C7 ORF mammalian expression plasmid, C-GFPSpark tag||HG13848-ACG|
|Human C7 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13848-ACR|
|Human C7 ORF mammalian expression plasmid, C-Flag tag||HG13848-CF|
|Human C7 ORF mammalian expression plasmid, C-His tag||HG13848-CH|
|Human C7 ORF mammalian expression plasmid, C-Myc tag||HG13848-CM|
|Human C7 ORF mammalian expression plasmid, C-HA tag||HG13848-CY|
|Human C7 Gene cDNA clone plasmid||HG13848-G|
|Human C7 ORF mammalian expression plasmid, N-Flag tag||HG13848-NF|
|Human C7 ORF mammalian expression plasmid, N-His tag||HG13848-NH|
|Human C7 ORF mammalian expression plasmid, N-Myc tag||HG13848-NM|
|Human C7 ORF mammalian expression plasmid, N-HA tag||HG13848-NY|
|Human C7 natural ORF mammalian expression plasmid||HG13848-UT|
|Learn more about expression Vectors|
Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and 2 TSP type-1 domains. Complement component 7 serves as a membrane anchor. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. It is a constituent of MAC that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.