|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Canine NOV ORF mammalian expression plasmid, C-GFPSpark tag||DG70043-ACG|
|Canine NOV ORF mammalian expression plasmid, C-OFPSpark / RFP tag||DG70043-ACR|
|Canine NOV ORF mammalian expression plasmid, C-Flag tag||DG70043-CF|
|Canine NOV ORF mammalian expression plasmid, C-His tag||DG70043-CH|
|Canine NOV ORF mammalian expression plasmid, C-Myc tag||DG70043-CM|
|Canine NOV ORF mammalian expression plasmid, C-HA tag||DG70043-CY|
|Canine NOV Gene cDNA clone plasmid||DG70043-G|
|Canine NOV ORF mammalian expression plasmid, N-Flag tag||DG70043-NF|
|Canine NOV ORF mammalian expression plasmid, N-His tag||DG70043-NH|
|Canine NOV ORF mammalian expression plasmid, N-Myc tag||DG70043-NM|
|Canine NOV ORF mammalian expression plasmid, N-HA tag||DG70043-NY|
|Canine NOV natural ORF mammalian expression plasmid||DG70043-UT|
|Learn more about expression Vectors|
Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is a putative ligand for integrin receptors, is tightly associated with the extracellular matrix and mediates diverse cellular functions, including cell adhesion and proliferation. CCN3 has been shown to negatively regulate growth although it promotes migration in a cell type-specific manner. This secreted protein belongs to the CCN family, and its expression was observed in a broad variety of tissues from the early stage of development , and altered expression of CCN3 has been observed in a variety of tumors, including hepatocellular carcinomas, Wilm's tumors, Ewing's sarcomas, gliomas, rhabdomyosarcomas, and adrenocortical carcinomas. Mature CCN3 protein has five distinct modules and truncated protein variants with altered function are found in many cancers. CCN3 acts through the core stem cell signalling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of a number of cell lineages including hematopoietic, osteogenic and chondrogenic. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis and a crucial component within the bone marrow microenvironment.