|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Canine NTRK2 ORF mammalian expression plasmid, C-GFPSpark tag||DG70035-ACG|
|Canine NTRK2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||DG70035-ACR|
|Canine NTRK2 ORF mammalian expression plasmid, C-Flag tag||DG70035-CF|
|Canine NTRK2 ORF mammalian expression plasmid, C-His tag||DG70035-CH|
|Canine NTRK2 ORF mammalian expression plasmid, C-Myc tag||DG70035-CM|
|Canine NTRK2 ORF mammalian expression plasmid, C-HA tag||DG70035-CY|
|Canine NTRK2 Gene cDNA clone plasmid||DG70035-G|
|Canine NTRK2 ORF mammalian expression plasmid, N-Flag tag||DG70035-NF|
|Canine NTRK2 ORF mammalian expression plasmid, N-His tag||DG70035-NH|
|Canine NTRK2 ORF mammalian expression plasmid, N-Myc tag||DG70035-NM|
|Canine NTRK2 ORF mammalian expression plasmid, N-HA tag||DG70035-NY|
|Canine NTRK2 natural ORF mammalian expression plasmid||DG70035-UT|
|Learn more about expression Vectors|
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.