|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Human F13B ORF mammalian expression plasmid, C-GFPSpark tag||HG11510-ACG|
|Human F13B ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11510-ACR|
|Human F13B ORF mammalian expression plasmid, C-Flag tag||HG11510-CF|
|Human F13B ORF mammalian expression plasmid, C-His tag||HG11510-CH|
|Human F13B ORF mammalian expression plasmid, C-Myc tag||HG11510-CM|
|Human F13B ORF mammalian expression plasmid, C-HA tag||HG11510-CY|
|Human F13B Gene cDNA clone plasmid||HG11510-M|
|Human F13B ORF mammalian expression plasmid, N-Flag tag||HG11510-NF|
|Human F13B ORF mammalian expression plasmid, N-His tag||HG11510-NH|
|Human F13B ORF mammalian expression plasmid, N-Myc tag||HG11510-NM|
|Human F13B ORF mammalian expression plasmid, N-HA tag||HG11510-NY|
|Human F13B natural ORF mammalian expression plasmid||HG11510-UT|
|Learn more about expression Vectors|
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 10 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Factor XIII acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Defects in F13B are the cause of factor XIII subunit B deficiency ( FA13BD ) which is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.