|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human OSM ORF mammalian expression plasmid, C-GFPSpark tag||HG10452-ACG|
|Human OSM ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10452-ACR|
|Human OSM ORF mammalian expression plasmid, C-Flag tag||HG10452-CF|
|Human OSM ORF mammalian expression plasmid, C-His tag||HG10452-CH|
|Human OSM ORF mammalian expression plasmid, C-Myc tag||HG10452-CM|
|Human OSM ORF mammalian expression plasmid, C-HA tag||HG10452-CY|
|Human OSM Gene cDNA clone plasmid||HG10452-M|
|Human OSM natural ORF mammalian expression plasmid||HG10452-M-N|
|Human OSM ORF mammalian expression plasmid, N-Flag tag||HG10452-NF|
|Human OSM ORF mammalian expression plasmid, N-His tag||HG10452-NH|
|Human OSM ORF mammalian expression plasmid, N-Myc tag||HG10452-NM|
|Human OSM ORF mammalian expression plasmid, N-HA tag||HG10452-NY|
|Human OSM natural ORF mammalian expression plasmid||HG10452-UT|
|Learn more about expression Vectors|
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors typeⅠand typeⅡ both of which share the similarity of containing protein gp130 and takes part in many biometabolism processes including liver development, haematopoeisis, inflammation, bone formation and destruction and possibly CNS development. Oncostatin M (OSM) was previoustly identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6 and G-CSF, has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degree but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-teminal most 31 amino acids produces the fully active 196 residue form.